PAUL H. LAVIETES, M.D.; FRANKLIN H. EPSTEIN, M.D.
With the general tendency to use the protein bound iodine of serum (PBI) to replace basal metabolism rate (BMR) determinations, the PBI is often used as a guide to replacement therapy in hypothyroidism. This practice may be very misleading. Although when desiccated thyroid is used for treatment, the PBI tends to be in the normal range, when triiodothyronine is used, the PBI may be almost nil in adequately treated patients (1, 2). It is known less commonly that when thyroxine is used to produce the euthyroid state, the PBI tends to be at or above the upper normal range (3,
LAVIETES PH, EPSTEIN FH. Thyroid Therapy of Myxedema: A Comparison of Various Agents with a Note on the Composition of Thyroid Secretion in Man. Ann Intern Med. ;60:79–87. doi: 10.7326/0003-4819-60-1-79
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Published: Ann Intern Med. 1964;60(1):79-87.
Endocrine and Metabolism, Thyroid Disorders.
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