THEODORE E. WOODWARD, M.D., F.A.C.P.; JOSEPH E. SMADEL, M.D.
Fifteen years have elapsed since chloramphenicol was first employed for the treatment of typhoid fever. During this period, it has become the accepted drug for the control of the acute typhoidal infection. We thought it worth-while to review the published experience with the use of this antibiotic in this disease and also to review the current concepts regarding the management of complications including the carrier state.
The treatment of patients with typhoid fever remained symptomatic and supportive until 1948 when, with our colleagues in Malaya, it was possible to demonstrate that chloramphenicol drastically shortens the
WOODWARD TE, SMADEL JE. Management of Typhoid Fever and Its Complications. Ann Intern Med. ;60:144–157. doi: 10.7326/0003-4819-60-1-144
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Published: Ann Intern Med. 1964;60(1):144-157.
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