CORNELIUS J. O'CONNELL, M.D.; DAVID T. KARZON, M.D.; ALMEN L. BARRON, PH.D.; MARTIN E. PLAUT, M.D.; VILAYAT M. ALI, M.D.
Of the several complications attending vaccination against smallpox, the rarest and most grave is the development of progressive vaccinia. In this disorder the primary vaccination site fails to undergo its usual evolution which normally leads to regression in the second week. On the contrary, it spreads, becoming deep and necrotic. Metastatic lesions appear at distant cutaneous and visceral sites, and most cases terminate fatally. Progressive vaccinia, thus defined, is synonymous with "vaccinia gangrenosa" and "vaccinia necrotica" and must be differentiated from the more common condition, generalized vaccinia (Kaposi's varicelliform eruption) in which widespread lesions occur but then proceed to evolve
O'CONNELL CJ, KARZON DT, BARRON AL, PLAUT ME, ALI VM. Progressive Vaccinia with Normal Antibodies: A Case Possibly Due to Deficient Cellular Immunity. Ann Intern Med. ;60:282–289. doi: 10.7326/0003-4819-60-2-282
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Published: Ann Intern Med. 1964;60(2_Part_1):282-289.
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