John W. Eckstein, M.D. (Associate)
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The arterial pressure depends upon the rate of blood flow into the arteries and the resistance to flow from them. Pressure may fall because of reduced cardiac output or reduced peripheral resistance, or both. It is common to attribute hypotension, regardless of the disease process, to decreased peripheral resistance and loss of arterial tone. Frequently, the reduced output is regarded as a contributing, but secondary, phenomenon caused by reduced coronary perfusion that results from the fall in aortic pressure. In reality, the low output often is a primary rather than a secondary event. A fall in cardiac output could result
Eckstein JW. Physiologic Effects of Pressor Agents.. Ann Intern Med. ;60:316–317. doi: 10.7326/0003-4819-60-2-316_3
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Published: Ann Intern Med. 1964;60(2_Part_1):316-317.
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