Sigmundur Gudbjarnason, M.D.; Richard J. Bing, M.D., F.A.C.P.; Chiyo Chiba, M.D.; Christian DeSchryver, M.D.; Jiro Yamanaka, M.D.
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Myocardial infarction was produced in dogs by ligation of branches of the coronary arteries. The rate of incorporation of a radioactive amino acid, glycine-2-C14, into heart muscle protein was studied over a period of six weeks. Three samples were analyzed from each left ventricle close to the infarcted area: normal tissue, the infarcted area, and borderline tissue.
The infarcted tissue showed a rapid diminution in protein synthesis after infarction, but already on the third day, the incorporation into the infarcted tissue rose above the normal and reached a maximum after 4 days. This reflects the early destruction and the following
Sigmundur Gudbjarnason, Richard J. Bing, Chiyo Chiba, Christian DeSchryver, Jiro Yamanaka. The Reaction of the Heart to Myocardial Infarction.. Ann Intern Med. 1964;60:320–321. doi: 10.7326/0003-4819-60-2-320_3
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Published: Ann Intern Med. 1964;60(2_Part_1):320-321.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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