Gerhard H. Muelheims, M.D.; Richard W. Entrup, M.D.; Donald Paiewonsky, M.D.; Donald S. Mierzwiak, M.D.
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Six healthy male subjects received a constant infusion of norepinephrine bitartrate at a concentration of 2 µg/min of the base that was then increased to 4 µg/min, 8 µg/min, 15 µg/min, and 20 µg/min. Each infusion period lasted 4 minutes. The blood pressure and electrocardiogram were determined at 2 and 4 minute intervals. The subjects then received 200 mg of guanethidine by mouth on the first day and 100 mg guanethidine on each of the 2 following days. The infusion of norepinephrine was repeated on the fourth day.
The preguanethidine infusion of norepinephrine elicited in all subjects a rise in
Gerhard H. Muelheims, Richard W. Entrup, Donald Paiewonsky, Donald S. Mierzwiak. Response of the Vascular System to Norepinephrine in Man After Oral Administration of Guanethidine.. Ann Intern Med. 1964;60:322. doi: 10.7326/0003-4819-60-2-322_1
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Published: Ann Intern Med. 1964;60(2_Part_1):322.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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