ALVAN R. FEINSTEIN, M.D.; MARIO SPAGNUOLO, M.D.; HARRISON F. WOOD, M.D.; ANGELO TARANTA, M.D.; ESTHER TURSKY, R.N.; EDITH KLEINBERG, B.S.
When a large group of children and adolescents is examined repetitively at monthly intervals after an attack of acute rheumatic fever, three main kinds of clinical events may be anticipated:  streptococcal infections,  recurrences of rheumatic fever, and  changes in cardiac status. A population of 431 young rheumatic patients, in whom these events could be observed, was originally assembled for long-term study of the antistreptococcal and antirheumatic effectiveness of three prophylactic regimens. The results of the prophylaxis study, and some selected correlations of the recurrent streptococcal and rheumatic inflammation, have been reported elsewhere (1-5).
Despite the continuous use
FEINSTEIN AR, SPAGNUOLO M, WOOD HF, TARANTA A, TURSKY E, KLEINBERG E. Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: VI. Clinical Features of Streptococcal Infections and Rheumatic Recurrences. Ann Intern Med. 1964;60:68–86. doi: 10.7326/0003-4819-60-2-68
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Published: Ann Intern Med. 1964;60(2_Part_2):68-86.
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