WILLIAM P. BALDUS, M.D.; RALPH N. FEICHTER, M.D.; WILLIAM H. J. SUMMERSKILL, M.D.; JAMES C. HUNT, M.D.; KHALIL G. WAKIM, M.D.
Impairment of renal function, including disorders of water and electrolyte metabolism, may develop spontaneously in patients with hepatic cirrhosis (1-4). The characteristics consist of the insidious development of azotemia progressing to terminal oliguria and hypotension in patients with severe impairment of hepatic function and ascites, who demonstrate neither evidence of primary renal disease nor secondary causes of azotemia (1). Additional clinical and biochemical features have been described, but the mechanisms of impairment of renal function and their relationship to the clinical findings have yet to be established. It has been shown that some patients with cirrhosis may have diminution of
WILLIAM P. BALDUS, RALPH N. FEICHTER, WILLIAM H. J. SUMMERSKILL, JAMES C. HUNT, KHALIL G. WAKIM. The Kidney in Cirrhosis: II. Disorders of Renal Function. Ann Intern Med. 1964;60:366–377. doi: 10.7326/0003-4819-60-3-366
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Published: Ann Intern Med. 1964;60(3):366-377.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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