ERIC A. SCHENK, M.D.
Recognition of the varied clinical manifestations of sickle cell hemoglobin and its disorders has been repeatedly emphasized in the medical literature. The sickle cell disorders are the result of the inheritance of a dominant gene which determines the presence of abnormal hemoglobin S. In the homozygous individual (hemoglobin S-S) usually over 90 per cent of red cell hemoglobin will be hemoglobin S, and the disease is manifest as sickle cell anemia. If the genetic constitution is heterozygous (hemoglobin S-A), hemoglobin S will constitute up to 50 per cent of red cell hemoglobin, the remainder being normal adult hemoglobin A (and
SCHENK EA. Sickle Cell Trait and Superior Longitudinal Sinus Thrombosis. Ann Intern Med. ;60:465–470. doi: 10.7326/0003-4819-60-3-465
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Published: Ann Intern Med. 1964;60(3):465-470.
Hematology/Oncology, Red Cell Disorders.
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