N. RAPHAEL SHULMAN, M.D.
Drug purpura (1-6), drug hemolytic anemia (7-9), and drug leukopenia (10-12) are now classic examples of diseases in which sensitization to a foreign antigen causes destruction of the sensitized individual's own cells. In these disorders, it is known (1, 2) that the drug somehow elicits antibody, and that the presence of drug is required for antibody to attach to the specific cells that are destroyed. However, the question of how antibodies against drug antigens become attached to autologous cells, the related questions of how a drug stimulates antibody, and why a particular cell type is affected have been matters of
SHULMAN NR. A Mechanism of Cell Destruction in Individuals Sensitized to Foreign Antigens and Its Implications in Auto-immunity: Combined Clinical Staff Conference at the National Institutes of Health. Ann Intern Med. ;60:506–521. doi: 10.7326/0003-4819-60-3-506
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Published: Ann Intern Med. 1964;60(3):506-521.
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