I. MICHAEL SAMLOFF, M.D.; MAURICE L. KELLEY, M.D., F.A.C.P.; VICTOR W. LOGAN, M.D., F.A.C.P.; ROGER TERRY, M.D.
Basic understanding of the disorder known as celiac disease or nontropical sprue, has increased in recent years largely due to the recognition of characteristic histopathological abnormalities in the intestinal mucosa obtained by peroral biopsy and the realization that exclusion of gluten from the diet frequently produces a clinical remission.
We feel it is worth-while to call attention to the patient described in this report to demonstrate and emphasize the following points.
1. Severe histopathological changes in jejunum may exist with negligible derangement of the established tests of intestinal absorption.
2. Peroral biopsy in this situation is the only means of
SAMLOFF IM, KELLEY ML, LOGAN VW, TERRY R. Severe Histopathological Lesion of Sprue in Patient with Minimal Evidence of Malabsorption: Serial Jejunal Biopsy and Clinical Observations. Ann Intern Med. 1964;60:673–679. doi: 10.7326/0003-4819-60-4-673
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Published: Ann Intern Med. 1964;60(4):673-679.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology.
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