Herbert A. Selenkow, M.D., F.A.C.P.; Antonio M. Garcia, M.D.
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The goitrogenic and therapeutic properties of stable iodide have been appreciated for many years, yet the nature, extent, and site of biochemical block remain unclear. In hyperthyroidism, iodide exerts a salutary effect by reducing thyroid hormone release through impedance of thyroglobulin proteolysis. This action, although evanescent, results from either direct inhibition of proteolytic enzymes or from interference with thyrotropic activity. More recently, iodide has also been shown to inhibit thyroidal oxidative iodination of tyrosine. This biochemical lesion is analogous to an inborn error of thyroid hormonogenesis causing goitrous cretinism.
Renewed interest in thyroidal iodide pathways has stimulated further investigation of
Selenkow HA, Garcia AM. Patterns of Iodide Inhibition of Thyroid Hormonogenesis.. Ann Intern Med. ;60:719. doi: 10.7326/0003-4819-60-4-719_2
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Published: Ann Intern Med. 1964;60(4):719.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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