K. O. Goh, M.D.; S. N. Swisher, M.D., F.A.C.P.
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An abnormal chromosome called "Philadelphia" or Ph1 has been demonstrated in the metaphase nuclei of hematopoietic cells of patients with chronic myelocytic leukemia. This chromosome has been identified in all of the 20 patients with chronic myelocytic leukemia. This chromosome has been identified in all of 20 patients with chronic myelocytic leukemia in various stages of the disease studied in this clinic. This abnormal chromosome was not found in 9 patients with myeloid metaplasia showing various clinical and hematological manifestations, including high or low values of leukocyte alkaline phosphatase. The Ph1 was not found in a normal identical twin of
K. O. Goh, S. N. Swisher. Studies of the Philadelphia Chromosome.. Ann Intern Med. 1964;60:729–730. doi: 10.7326/0003-4819-60-4-729_2
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Published: Ann Intern Med. 1964;60(4):729-730.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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