Elisha Atkins, M.D.
This content is PDF only. Please click on the PDF icon to access.
Though fever has played a prominent role in the history of medicine, little has been learned until recently about its pathogenesis.
Various experimental models to investigate the cause of fever will be discussed. Most of these involve experimental infections or the intravenous injection of microbial materials into rabbits or dogs. In other instances, fevers of hypersensitivity have been induced by injection of antigen in specifically sensitized animals. On the basis of this work, it is postulated that most pyrogenic agents induce fever by releasing an intermediate circulating pyrogen from the tissues of the host. This pyrogen is believed to act
Elisha Atkins. Experimental Models in Studies in the Pathogenesis of Fever.. Ann Intern Med. 1964;60:732. doi: 10.7326/0003-4819-60-4-732_1
Download citation file:
Published: Ann Intern Med. 1964;60(4):732.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use