HARRY W. DANIELL
Long-term methysergide maleate (Sansert®) administration has recently been advocated as an effective preventative for vascular headaches. Reports of its effectiveness are well documented (1-3), and its use appears to be expanding rapidly. Few serious side effects have been reported, although occasional patients have reported the onset of vasospastic symptoms, including angina pectoris (1, 4) or intermittent claudication of the calf muscles (1, 3). These symptoms have disappeared with decrease in dosage or discontinuation of the medication. The mechanism by which methysergide induces vessel spasm is not understood, and pharmacologic attempts at modifying this unusual effect have not been reported.
HARRY W. DANIELL. Vasospastic Reaction to Methysergide Maleate Simulating Leriche Syndrome: Ineffective Treatment with Adrenergic Blockade. Ann Intern Med. 1964;60:881–885. doi: 10.7326/0003-4819-60-5-881
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Published: Ann Intern Med. 1964;60(5):881-885.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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