MARCEL FRENKEL, M.D.; EDWARD N. EHRLICH, M.D.
Exacerbations of myasthenia gravis have been associated with pregnancy as well as the premenstrual phase of the reproductive cycle (1, 2). Since increasing rates of progesterone production are characteristic of pregnancy and the normal premenstruum, it seemed likely that progesterone might be responsible for the diminution of strength in these circumstances. The fact that progesterone can significantly influence electrolyte balance by virtue of its capacity to inhibit the salt-retaining activity of mineralocorticoids (3) provides a means of relating the metabolic properties of progesterone to alterations of muscle function. Any effect upon sodium or potassium exchange resulting from a fluctuation in
FRENKEL M, EHRLICH EN. The Influence of Progesterone and Mineralocorticoids upon Myasthenia Gravis. Ann Intern Med. 1964;60:971–981. doi: 10.7326/0003-4819-60-6-971
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Published: Ann Intern Med. 1964;60(6):971-981.
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