ALVIN J. CUMMINS, M.D., F.A.C.P.; MICHAEL L. GOMPERTZ, M.D., F.A.C.P.; JOHN H. KIER, M.D.
There is great need for a simple reliable test for the detection of gastric malignancy and its differentiation from benign lesions. Recently, several investigators have reported on the use of tetracycline fluorescence of the gastric sediment in such detection and most of the reports have indicated a rather high degree of diagnostic accuracy (1-4).
The tetracycline drugs are known to fluoresce bright yellow in ultraviolet light of 3,600 Å, and this observation has been used to trace the absorption and distribution of the drug (5). Tetracycline-induced fluorescence disappears from normal tissues, except bone and teeth, within 24 hours (6, 7).
CUMMINS AJ, GOMPERTZ ML, KIER JH. An Evaluation of the Tetracycline-fluorescence Test in the Diagnosis of Gastric Cancer: Comparison with Cytology. Ann Intern Med. ;61:56–63. doi: 10.7326/0003-4819-61-1-56
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Published: Ann Intern Med. 1964;61(1):56-63.
Gastric Cancer, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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