JAMES F. TOOLE, M.D., F.A.C.P.
Doctors Siekert, Millikan, and Whisnant, whose article appears in this issue of the ANNALS, have made many significant contributions to our understanding of the etiology and treatment of the atherosclerotic forms of cerebral vascular disease. Their publications span the years when there has been such a great reawakening of interest in this problem.
Prior to 1950, "strokes" or "C.V.A.'s" were thought to follow thrombosis of small intracranial arteries, so that the physician directed his therapy at the prevention of the complications of bed rest and not at the primary cerebral-vascular problem. Then Wright and his co-workers (1, 2) published their
TOOLE JF. Reversed Vertebral Artery Flow and Cerebral Vascular Insufficiency. Ann Intern Med. ;61:159–162. doi: 10.7326/0003-4819-61-1-159
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Published: Ann Intern Med. 1964;61(1):159-162.
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