FRANK Q. NUTTALL, M.D.; RICHARD P. DOE, M.D.
In spite of the plethora of thyroid function tests currently available to the clinician, only two tests represent measurements of end-organ or tissue response to changes in thyroid function. These are the basal metabolism rate (BMR) and the serum cholesterol test. Both are rather non-specific and subject to great error. They usually rank low among tests of thyroid function. The desirability of having a more specific and direct measure of the peripheral effect of thyroid hormones is obvious. The slowing of reflexes has long been held in esteem by clinicians as a near pathognomonic sign in myxedema. The brisk reflex
NUTTALL FQ, DOE RP. The Achilles Reflex in Thyroid Disorders: A Critical Evaluation. Ann Intern Med. ;61:269–288. doi: 10.7326/0003-4819-61-2-269
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Published: Ann Intern Med. 1964;61(2):269-288.
Endocrine and Metabolism, Neurology, Thyroid Disorders.
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