ARTHUR A. COOPERBERG, M.D., F.A.C.P.; JACK SCHWARTZ, M.D.
Disseminated histoplasmosis is a systemic fungus disease characterized by weakness, weight loss, fever, hepatosplenomegaly, anemia, and frequently by leukopenia. The diagnosis is based on visualization of the intracellular organisms in biopsy material or on culture of sputum, blood, bone marrow, urine, cerebrospinal fluid, and liver from a biopsy specimen.
Although reference is frequently made to bone marrow cultures (1-3), too little attention has been paid to the direct examinations of the marrow smears in the diagnosis of disseminated histoplasmosis. The organisms have indeed been described on occasion in the bone marrow (4-11), but little use appears to have been made
COOPERBERG AA, SCHWARTZ J. The Diagnosis of Disseminated Histoplasmosis from Marrow Aspiration. Ann Intern Med. ;61:289–295. doi: 10.7326/0003-4819-61-2-289
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Published: Ann Intern Med. 1964;61(2):289-295.
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