STANLEY MINKOWITZ, M.D.
Arsenical preparations were first related etiologically to epidermoid carcinomata when Jonathan Hutchinson incriminated them in 1887 (1-8). Notably multicentric in origin these malignancies are generally preceded and accompanied by disseminated keratoses and precanceroses, and tend to appear in a younger population than do similar nonarsenical forms of cancer (4, 5, 8, 9). Like late radiation neoplasia, a variable, rather long latent period is frequently observed between the time of exposure to the implicated arsenical and the clinical appearance of the neoplasm. The purpose of this paper is to re-emphasize that arsenical carcinomata are potentially extremely malignant lesions and that endless,
MINKOWITZ S. Multiple Carcinomata Following Ingestion of Medicinal Arsenic. Ann Intern Med. ;61:296–299. doi: 10.7326/0003-4819-61-2-296
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Published: Ann Intern Med. 1964;61(2):296-299.
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