WILLIAM T. BUTLER, M.D.
Reported abnormalities of renal function after treatment with amphotericin B are listed on Table 1. During treatment with the colloidal form of amphotericin B (Fungizone® for Infusion), the form available for clinical use, over five sixths of patients have developed abnormal blood urea nitrogen or serum creatinine levels (1). In this regard it is noteworthy that in most instances the daily dosage of drug has been dependent more on the level
of azotemia present than upon the therapeutic response of the patient. In most early reports, however, authors have felt that these renal abnormalities were reversible after discontinuation of the
BUTLER WT. Changes in Renal Function. Ann Intern Med. 1964;61:344–349. doi: 10.7326/0003-4819-61-2-344
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Published: Ann Intern Med. 1964;61(2):344-349.
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