ARTHUR LORBER, M.D.; CARL M. PEARSON, M.D., F.A.C.P.; WROTHER L. MEREDITH, B.A.; LOUISE E. GANTZ-MANDELL, B.A.
Sulfhydryl (SH) groups are chemically reactive sites located on protein molecules. Oxidation of these groups results in the formation of disulfide bonds (S-S) (1), thereby interlinking the protein molecules and forming macroglobulins. These serum macroglobulins may be dissociated into their protein subunits by thiol (sulfhydryl-containing) compounds that have the ability to break the disulfide bonds (2-5). The importance of sulfhydryl groups in the formation of macroglobulins is further implied by the virtual absence of these groups in the abnormal protein found in Waldenstrom's macroglobulinemia (2) and by the decreased serum sulfhydryl levels reported in other related neoplastic disorders (6).
LORBER A, PEARSON CM, MEREDITH WL, GANTZ-MANDELL LE. Serum Sulfhydryl Determinations and Significance in Connective Tissue Diseases. Ann Intern Med. ;61:423–434. doi: 10.7326/0003-4819-61-3-423
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Published: Ann Intern Med. 1964;61(3):423-434.
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