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The early enthusiasm for surgery generated by Goldblatt's classical studies of renal hypertension was soon tempered by the realization that unilateral nephrectomy did not predictably reduce blood pressure and in many instances actually accelerated clinical deterioration of patients so treated. Homer Smith's superb critical study of the problem (J. Urol. 76: 685, 1956) in large measure restored the clinical balance until the introduction of split renal function testing by Howard and his associates coupled with widespread use of arteriographic techniques re-opened the problem for serious study. Since then we have learned of the relationship of the renin-angiotensin system to the
Correctable Renal Hypertension.. Ann Intern Med. ;61:602–603. doi: 10.7326/0003-4819-61-3-602_3
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Published: Ann Intern Med. 1964;61(3):602-603.
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