JOHN E. ULTMANN, M.D., F.A.C.P.
The reaction to smallpox vaccination is usually trivial and self-limited. Of five million people vaccinated in New York City in 1947, only seven, having no antecedent eczema, developed generalized vaccinia, an incidence of 1: 710,000 vaccinations (1). In 1953, the year following Bruton's (2) description of agammaglobulinemia, Keidan, McCarthy, and Haworth (3) reported a case of generalized vaccinia in an infant with absence of serum gamma globulin. Two, possibly three adults with secondary hypogammaglobulinemia due to chronic lymphocytic leukemia or lymphocytic lymphosarcoma have been reported to develop generalized vaccinia following smallpox vaccination (4-6). The present additional case is presented to
ULTMANN JE. Generalized Vaccinia in a Patient with Chronic Lymphocytic Leukemia and Hypogammaglobulinemia. Ann Intern Med. ;61:728–732. doi: 10.7326/0003-4819-61-4-728
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Published: Ann Intern Med. 1964;61(4):728-732.
Hematology/Oncology, Infectious Disease, Leukemia/Lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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