M. H. Weil, M.D., Ph.D.
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Vasopressor amines are widely used for treatment of acute hypotension and circulatory shock in an effort to restore "normal" or near-normal arterial pressure levels. The circulatory failure clinically regarded as "shock" is primarily a defect of blood flow rather than a deficiency of blood pressure, and vasoconstriction provoked by vasopressor agents may not improve perfusion of vital tissues. The actions of various vasopressor amines in current clinical use were defined in terms of their relative effects on the arterial bed (resistance vessels), the venous bed (capacitance vessels), and the heart. Fundamental differences between vasopressor agents were demonstrated, and the implication
Weil MH. Fundamental Differences in the Circulatory Effects of Various Vasoactive Drugs Used for the Treatment of Shock.. Ann Intern Med. 1964;61:798. doi: 10.7326/0003-4819-61-4-798_2
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Published: Ann Intern Med. 1964;61(4):798.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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