Patrick H. Lehan, M.D.; H. A. Oldewurtel, M.D.; P. Casanegra, M.D.; H. K. Hellems, M.D. (Associate)
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A method for rapid and repeated determinations of coronary blood flow (CBF) has been devised in dogs using the potentiometric hydrogen electrode. After a brief inhalation of hydrogen gas, the oxidation-reduction potential of the electrodes placed in the coronary sinus and discrete areas of the myocardium were recorded. Left ventricular and regional flow were determined from the slope constant of the hydrogen clearance curves obtained from the coronary sinus and ventricular tissue. Reproducible CBF ranging from 40 to 110 ml/100 g/min were obtained in anesthetized dogs.
Studies of regional myocardial flow after coronary artery ligation revealed two distinct flow patterns.
Lehan PH, Oldewurtel HA, Casanegra P, Hellems HK. Coronary Sinus and Myocardial Tissue Blood Flow Determined by the Hydrogen Electrode.. Ann Intern Med. ;61:799. doi: 10.7326/0003-4819-61-4-799_1
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Published: Ann Intern Med. 1964;61(4):799.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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