Hyman Engelberg, M.D., F.A.C.P.
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Several years ago Chandler developed a simple method for the in vitro production of thrombi using recalcified citrated whole blood. Essentially the method involves placing blood in a closed loop plastic tubing, which is then rotated at a speed approximating that of the blood flow in man. A platelet-head thrombus forms and the time it takes to do so is called the thrombus formation time. This technique lends itself well to the study of the relationship of various other circulating factors to the tendency of the blood to form a thrombus. Since the endpoint is a thrombus the method may
Engelberg H. The Relationship to Serum Cholesterol, Triglycerides, and Hematocrit to the Thrombosis of Human Blood in Vitro.. Ann Intern Med. ;61:806. doi: 10.7326/0003-4819-61-4-806_1
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Published: Ann Intern Med. 1964;61(4):806.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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