Shannon Brunjes, M.D., F.A.C.P.
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Daytime catecholamine and catecholamine metabolite excretion is compared in 73 patients with "essential" hypertension and 47 normal individuals. The hypertensives as a group show significantly lower values for epinephrine, norepinephrine, metanephrine, and vanillylmandelic acid. These differences may be secondary to a reduced sympathetic activity when blood pressure is maintained by some other mechanism. However, in 19% of the hypertensives the ratio of metanephrine plus normetanephrine to vanillylmandelic acid is markedly elevated, indicating an abnormality of catecholamine metabolism. In these patients abnormal catecholamine deactivation may cause their hypertension.
Shannon Brunjes. Catecholamine Metabolism in Essential Hypertension.. Ann Intern Med. 1964;61:811–812. doi: 10.7326/0003-4819-61-4-811_4
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Published: Ann Intern Med. 1964;61(4):811-812.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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