Boy Frame, M.D., F.A.C.P.; George Karpati, M.D.
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Endocrine disorders often cause mental and neuromuscular changes. Clinical analysis of 33 histologically proven cases of primary hyperparathyroidism (PHPT) was undertaken in an attempt to establish the incidence and type of neuropsychiatric disorders encountered. In 14 cases of PHPT, subjective or objective neuropsychiatric, or both, manifestations occurred. In four cases these signs dominated the clinical picture so that neurologic or psychiatric consultation was obtained before the diagnosis of PHPT had been established. Headache, muscle weakness, and mental changes were found to be prevalent and, in most instances, disappeared following parathyroid surgery. In general, neuropsychiatric signs correlated directly with the level
Frame B, Karpati G. Psychiatric and Neuromuscular Manifestations in Primary Hyperparathyroidism.. Ann Intern Med. ;61:812. doi: 10.7326/0003-4819-61-4-812_1
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Published: Ann Intern Med. 1964;61(4):812.
Endocrine and Metabolism, Neurology, Parathyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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