Robert E. Tranquada, M.D.
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The metabolic roles of lactate and pyruvate have been well described. However, the clinical significance of elevations of blood lactate out of proportion to pyruvate are just beginning to be understood. We studied 35 patients representing a variety of underlying diseases, all of whom were found to have a metabolic acidosis (arterial pH < 7.30), frequently of great severity, accompanied by a rise in blood lactate to 10 mEq/liter or more, and an increase in the ratio of blood lactate to pyruvate of greater than 16. There were 14 males and 21 females, of whom 24 were white and 11
Tranquada RE. The Clinical Significance of Lactic Acidosis.. Ann Intern Med. 1964;61:812. doi: 10.7326/0003-4819-61-4-812_3
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Published: Ann Intern Med. 1964;61(4):812.
Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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