John E. Peterson, M.D., F.A.C.P.; D. I. Peterson, M.D.; M. G. Hardinge, M.D.; W. E. C. Wacker, M.D.
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Treatment with ethanol protects rats and monkeys from certain lethal effects of ethylene glycol that are attributed to products of enzymatic oxidation rather than to the glycol itself. In treated rats, the LD50 for ethylene glycol is almost doubled. Five squirrel monkeys protected with ethanol survived a lethal dose of ethylene glycol while five other monkeys receiving similar amounts of glycol and having no subsequent treatment with ethanol died.
Oxidation of ethylene glycgol is catalyzed by LADH, and catalysis is inhibited by ethanol, which has a high catalytic constant. When treated with ethanol, animals appear to oxidize ethylene glycol more
Peterson JE, Peterson DI, Hardinge MG, Wacker WEC. Experimental Treatment of Poisoning Due to Ethylene Glycol and Halogenated Ethanols.. Ann Intern Med. ;61:813. doi: 10.7326/0003-4819-61-4-813_1
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Published: Ann Intern Med. 1964;61(4):813.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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