JOHN P. PHAIR, M.D.; ROBERT E. ANDERSON, M.D.; HIDEO NAMIKI, M.D.
This report describes the central nervous system lesions in 165 cases of leukemia autopsied at the Atomic Bomb Casualty Commission (ABCC). Primary emphasis is placed upon the pathogenesis of intracerebral hemorrhage (1-7). The present study strongly implicates a grossly elevated leukocyte count (> 50,000/mm3) in the genesis of such lesions. Thrombocytopenia, while of some significance, appears to be of secondary importance. Additional correlations are made between central nervous system pathology and age, type of leukemia, and antileukemic therapy.
Two unique features characterize the group of persons studied. Some were exposed to varying amounts of ionizing radiation at the time of
PHAIR JP, ANDERSON RE, NAMIKI H. The Central Nervous System in Leukemia. Ann Intern Med. ;61:863–875. doi: 10.7326/0003-4819-61-5-863
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Published: Ann Intern Med. 1964;61(5_Part_1):863-875.
Hematology/Oncology, Leukemia/Lymphoma, Neurology.
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