J. M. QUAGLIANA, M.D.; G. E. CARTWRIGHT, M.D.; M. M. WINTROBE, M.D., PH.D., F.A.C.P.
Paroxysmal Nocturnal Hemoglobinuria (PNH) (1,2) is a rare disorder of unknown etiology characterized by an intracorpuscular defect that renders erythrocytes more susceptible to hemolysis in an acid medium. The disease is characterized by a chronic hemolytic anemia that is usually accompanied by leukopenia, thrombocytopenia, erythroid hyperplasia of the bone marrow, hemoglobinemia, hemoglobinuria, and hemosiderinuria. The course is often complicated by recurrent infections and venous thromboses. Because of the varied and often bizarre clinical picture, the correct diagnosis may not be made despite long periods of observation and study (3).
Bone marrow failure has been observed to occur during the course
QUAGLIANA JM, CARTWRIGHT GE, WINTROBE MM. Paroxysmal Nocturnal Hemoglobinuria Following Drug-induced Aplastic Anemia. Ann Intern Med. ;61:1045–1052. doi: 10.7326/0003-4819-61-6-1045
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Published: Ann Intern Med. 1964;61(6):1045-1052.
Hematology/Oncology, Red Cell Disorders.
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