LAURENCE H. KEDES, M.D.; JAMES V. BONESSI, M.D.; T. S. DANOWSKI, M.D., F.A.C.P.
This report describes an unusual instance of supraoptic-hypophyseal diabetes insipidus (SHDI) with documented complete spontaneous remissions that meets the criteria of an intermittent or incomplete disease state (1). In addition the patient also exhibited an acquired unresponsiveness to a commercial vasopressin preparation (Pitressin).
T. L., a white male, developed polyuria and polydipsia at the age of 12 years. There was no family history of excessive water drinking and no preceding trauma or serious illness. Studies at Children's Hospital of Pittsburgh established that the specific gravity of the urine remained very low (1.001 to 1.006) despite water deprivation
LAURENCE H. KEDES, JAMES V. BONESSI, T. S. DANOWSKI. Intermittent Supraoptic-hypophyseal Diabetes Insipidus with Acquired Pitressin Resistance. Ann Intern Med. 1964;61:1128–1133. doi: 10.7326/0003-4819-61-6-1128
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Published: Ann Intern Med. 1964;61(6):1128-1133.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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