W. E. C. WILSON, M.D.; CHARLES H. KIRKPATRICK, M.D.; DAVID W. TALMAGE, M.D.
Recent developments in surgery have resulted in technically successful transplantation of human kidneys prior to the solution of many fundamental problems in transplantation immunology. The consequence has been a spectrum of clinical observations that varies from generally successful renal transplantation between identical twins to less frequent success when a genetically dissimilar donor is employed. Nevertheless, when comparison is made with the fate of other transplanted organs that elicit an immune response, a remarkable degree of success has been achieved with human kidney allografts. These favorable results suggested that the chronically uremic patient may have a unique alteration of his immunologic
WILSON WEC, KIRKPATRICK CH, TALMAGE DW. Suppression of Immunologic Responsiveness in Uremia. Ann Intern Med. ;62:1–14. doi: 10.7326/0003-4819-62-1-1
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Published: Ann Intern Med. 1965;62(1):1-14.
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