JOHN F. MAHER, M.D., F.A.C.P.; GEORGE E. SCHREINER, M.D., F.A.C.P.
The therapy of edema has been made practical by modern diuretics. The wide variety of saluretic agents in current use may be categorized into a few groups: the organic mercurials, the benzothiadiazines, carbonic anhydrase inhibitors, aldosterone antagonists, theophilline derivatives, and osmotic diuretics. Ethacrynic acid, a new and potent saluretic agent, is chemically unrelated to the agents now in use. Chemically it is 2-3 dichloro-4-(2-methylenebutyrl) phenoxyacetic acid.
Preliminary studies (3-5) attest to its potency in the dog and man. We have studied this drug in patients with refractory edema to determine its effectiveness under adverse clinical and chemical conditions, to attempt
MAHER JF, SCHREINER GE. Studies on Ethacrynic Acid in Patients with Refractory Edema. Ann Intern Med. 1965;62:15–29. doi: 10.7326/0003-4819-62-1-15
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Published: Ann Intern Med. 1965;62(1):15-29.
Hospital Medicine, Nephrology.
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