KONG-OO GOH, M.D.; SCOTT N. SWISHER, M.D.; CHARLES A. ROSENBERG, M.D.
Frequently moderate degrees of hyper-eosinophilia have been found to be associated with many diseases (1). However, there are occasional cases in which the eosinophilia cannot be ascribed to a primary disease. Some of these cases are thought to be either myelocytic leukemia of eosinophilic variety or eosinophilic leukemia (2, 3).
In 1960, Nowell and Hungerford (4) described an abnormal small acrocentric chromosome in patients with chronic myelocytic leukemia. This abnormal chromosome has been called the Philadelphia chromosome or Ph1 (5). This abnormal chromosome has been thought to be typical of chronic myelocytic leukemia by many authors (6-9). Experience in this
GOH K, SWISHER SN, ROSENBERG CA. Cytogenetic Studies in Eosinophilic Leukemia: The Relationship of Eosinophilic Leukemia and Chronic Myelocytic Leukemia. Ann Intern Med. ;62:80–86. doi: 10.7326/0003-4819-62-1-80
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Published: Ann Intern Med. 1965;62(1):80-86.
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