ANANDA S. PRASAD, M.B., B.S., PH.D.; M. DIWANY, M.D., M.R.C.P.; MAMDOUH GABR, M.D.; HAROLD H. SANDSTEAD, M.D.; NEWAL MOKHTAR, M.B., B.S.; ANISA EL HEFNY, M.B., B.S.
Since the description of a syndrome comprised of erythroblastosis, splenomegaly, and anemia with a familial and racial incidence by Cooley and Lee (1) in 1925, many cases from various parts of the world have been reported (2-4). From Egypt, Diwany (5) first reported two cases in 1944, and since then others have been described (6-9). These reports have documented the presence of this disease in Egypt, but do not provide detailed biochemical and hematological data on the cases.
Abnormal iron metabolism in Cooley's anemia (thalassemia) has been established (10-12), and the presence of high serum levels of copper has been
PRASAD AS, DIWANY M, GABR M, SANDSTEAD HH, MOKHTAR N, HEFNY AE. Biochemical Studies in Thalassemia. Ann Intern Med. 1965;62:87–96. doi: 10.7326/0003-4819-62-1-87
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Published: Ann Intern Med. 1965;62(1):87-96.
Hematology/Oncology, Red Cell Disorders.
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