H. SHERWOOD LAWRENCE, M.D.
Of the many enigmas arising from studies of the immunology of homograft rejection, one of the more elusive has been the mechanism that favors prolonged survival of renal homografts in sick people, while skin homografts exchanged between normal individuals undergo prompt rejection. An early pre-occupation with this apparent paradox led Dammin, Couch, and Murray (1) to study the role of uremia in conditioning the human host's response to skin homografts. They found the survival times of skin homografts applied to uremic subjects was greatly prolonged (32 to 115 days) compared to the usual 8- to 10-day average survival time found
LAWRENCE HS. Uremia—Nature's Immunosuppressive Device. Ann Intern Med. ;62:166–170. doi: 10.7326/0003-4819-62-1-166
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Published: Ann Intern Med. 1965;62(1):166-170.
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