H. FRANKLIN BUNN, M.D.; GLENN D. LUBASH, M.D.
Management of the patient comatose from barbiturates rests on maintenance of vital functions with meticulous attention to respiratory toilet (1). Other regimens employed to remove the toxic agent directly include hemodialysis, peritoneal dialysis, and attempts to increase urinary excretion of drug by liberal fluid administration, alkalinization, and osmotic agents (2-5). The value of these ancillary measures is supported for the most part by clinical impressions of shortened duration of coma and by reduced blood levels of drug. Induced diuresis has recently received much attention, but data demonstrating increased clearances of short and intermediate acting drugs have been scanty. In a
BUNN HF, LUBASH GD. A Controlled Study of Induced Diuresis in Barbiturate Intoxication. Ann Intern Med. ;62:246–251. doi: 10.7326/0003-4819-62-2-246
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Published: Ann Intern Med. 1965;62(2):246-251.
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