JOSEPH LEE HOLLANDER, M.D., F.A.C.P.; DANIEL J. MCCARTY JR., M.D., F.A.C.P.; GONZALO ASTORGA, M.D.; EDUARDO CASTRO-MURILLO, M.D.
The etiology and pathogenesis of rheumatoid arthritis are not known. Many studies have described the clinical and pathological characteristics of the disease process. Numerous additional studies have produced evidence that disorders of immunity are involved, that is, that rheumatoid arthritis and associated diseases may be "immunodyscrasias." Little evidence has been forthcoming to bridge the gap between the clinical features of rheumatoid arthritis and the disordered immunological mechanisms involved.
The purpose of this and the next two reports is to describe preliminary findings that may help to clarify the pathogenetic mechanism of rheumatoid arthritis, although the etiology remains unknown. The original
HOLLANDER JL, MCCARTY DJ, ASTORGA G, CASTRO-MURILLO E. Studies on the Pathogenesis of Rheumatoid Joint Inflammation: I. The "R.A. Cell" and a Working Hypothesis. Ann Intern Med. 1965;62:271–280. doi: 10.7326/0003-4819-62-2-271
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Published: Ann Intern Med. 1965;62(2):271-280.
Rheumatoid Arthritis, Rheumatology.
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