RONALD A. RESTIFO, M.D.; ANDRE J. LUSSIER, M.D.; ARNOLD J. RAWSON, M.D.; JOHN H. ROCKEY, M.D.; JOSEPH LEE HOLLANDER, M.D., F.A.C.P.
The finding of leukocytes containing cytoplasmic inclusion granules ("R.A. cells") in the synovial fluids of rheumatoid patients has stimulated an hypothesis for the pathogenesis of the inflammatory changes in this disease (1). This proposes that the inflamed joint results from the phagocytosis of intra-articular complexes of rheumatoid factor and 7S gamma globulin by leukocytes. Supporting such a concept are the release of rheumatoid factor from washed rheumatoid synovial fluid cells fractured by ultrasound (2), the demonstration of intracytoplasmic particulate 7S and 19S gamma globulin in rheumatoid synovial fluid leukocytes (3), and the in vitro phagocytosis of complexes of rheumatoid factor
RESTIFO RA, LUSSIER AJ, RAWSON AJ, ROCKEY JH, HOLLANDER JL. Studies on the Pathogenesis of Rheumatoid Joint Inflammation: III. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma Globulin. Ann Intern Med. ;62:285–291. doi: 10.7326/0003-4819-62-2-285
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Published: Ann Intern Med. 1965;62(2):285-291.
Rheumatoid Arthritis, Rheumatology.
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