HOWARD M. SILBY, M.D.; ROGER FARBER, M.D.; CORNELIUS J. O'CONNELL, M.D.; JULIAN ASCHER, M.D.; EDWARD J. MARINE, M.D.
Arthritis has been described as an occasional complication of several viral diseases. However, to the authors' knowledge, the isolation of a specific virus from human synovial fluid in such cases has not been reported previously. The present report documents a case of acute monarticular arthritis after smallpox vaccination in which vaccinia virus was recovered from the synovial fluid.
E. J. (BGH 293446), a 65-year-old Negro female, was admitted to the Buffalo General Hospital on June 25, 1963, because of fever and a painful swelling of the right knee. Twelve days previously, at her request, she had been vaccinated
SILBY HM, FARBER R, O'CONNELL CJ, ASCHER J, MARINE EJ. Acute Monarticular Arthritis After Vaccination: Report of a Case with Isolation of Vaccinia Virus from Synovial Fluid. Ann Intern Med. ;62:347–350. doi: 10.7326/0003-4819-62-2-347
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Published: Ann Intern Med. 1965;62(2):347-350.
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