G. MILTON SHY, M.D.
Striated muscle of the human has not been exempted from the intense effort of modern day medicine to localize metabolic and molecular disorders at cellular and subcellular levels. Of the many new such disorders affecting striated muscle, perhaps the most classical is that of phosphorylase deficiency. In 1951 McArdle (1) first described a disorder in a young man who, after exercise, suffered from severe cramps and periodic myoglobinuria. Noting that after ischemic exercise the blood lactate and pyruvate levels did not rise in this young man, McArdle postulated an abnormality in the breakdown of glycogen in the Embden-Meyerhof cycle. He
SHY GM. Muscle Phosphorylase Deficiency. Ann Intern Med. ;62:409–411. doi: 10.7326/0003-4819-62-2-409
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Published: Ann Intern Med. 1965;62(2):409-411.
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