H. EDWARD HOLLING, M.D., F.A.C.P.
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In 1951, McArdle of Guy's hospital described a patient with intermittent claudication due to the difficulty with which the glycogen in his muscles was broken down. Until that time almost the only known cause of pain in working muscles was a deficiency in their blood supply.
As a colleague of McArdle at that time, I remember his patient as a 30-year-old man who complained of pain in his calves and thighs after walking three blocks and muscular pains in his arms caused by manual work. He was a short but otherwise well-formed adult in whom no physical abnormality could be
HOLLING HE. The Birth of a Syndrome. Ann Intern Med. ;62:412. doi: 10.7326/0003-4819-62-2-412
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Published: Ann Intern Med. 1965;62(2):412.
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