MORTIMER J. LACHER, M.D.; JOHN R. DURANT, M.D.
Until recently, only X-ray therapy and the alkylating agents were known to be useful for the treatment of Hodgkin's disease. Over the past 6 years, investigation has shown that the periwinkle derivatives, vinblastine and vincristine, also have considerable use, and of these two, vinblastine is less toxic and more effective in patients with Hodgkin's disease. Much information has been accumulated about this agent, but as yet its place is not fully established. In part, this is due to conflicting reports of its effectiveness and toxicity. Many physicians have been frightened by early reports such as that of Hall (1) in
LACHER MJ, DURANT JR. Combined Vinblastine and Chlorambucil Therapy of Hodgkin's Disease. Ann Intern Med. 1965;62:468–476. doi: 10.7326/0003-4819-62-3-468
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Published: Ann Intern Med. 1965;62(3):468-476.
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