RICHARD J. COHEN; RICHARD C. SEVERANCE; EDWARD G. WHITING; GEORGE D. LUNDBERG
It has been postulated recently that an interdependent system involving renin, angiotensin, and aldosterone may be involved in the production of certain types of human hypertension (1, 2). A number of studies have demonstrated an interaction of renin with angiotensin I to form angiotensin II (3-5), which stimulates aldosterone secretion by the zona glomerulosa of the adrenal cortex (3, 6-8). Aldosterone, by means of its potent mineralocorticoid effect on sodium and potassium balance, produces an elevation in systemic arterial blood pressure (2-9). The use of microdissection (10-13) and fluorescent antibody techniques (14) has localized renin production to the juxtaglomerular body
COHEN RJ, SEVERANCE RC, WHITING EG, LUNDBERG GD. A Study of the Juxtaglomerular Body in Primary Aldosteronism. Ann Intern Med. 1965;62:569–575. doi: 10.7326/0003-4819-62-3-569
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Published: Ann Intern Med. 1965;62(3):569-575.
Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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