CHRISTOPHER C. FORDHAM III, M.D., F.A.C.P.; WILLIAM D. HUFFINES, M.D.; LOUIS G. WELT, M.D., F.A.C.P.
There is a growing body of clinical evidence suggesting a relationship between the excessive ingestion of analgesic medication and the development of chronic renal disease. The evidence is almost wholly circumstantial in character, and the available epidemiologic data are suggestive but not thoroughly convincing (1, 2). Acetophenetidin (phenacetin) or some metabolic product thereof has been the suspected offending agent in analgesic preparations on similar grounds. Although many efforts have been made to develop a reproducible experimental renal disease in laboratory animals using the ingredients of analgesic preparations, most have met with failure, and no reliable model has thus far been
FORDHAM CC, HUFFINES WD, WELT LG. Phenacetin-induced Renal Disease in Rats. Ann Intern Med. ;62:738–743. doi: 10.7326/0003-4819-62-4-738
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Published: Ann Intern Med. 1965;62(4):738-743.
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