FRANK A. GRAIG, M.D.; J. CRISPIN SMITH, PH.D.
To the Editor: We read with great interest the recent paper by Hess and associates, entitled "Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle" (Ann. Intern. Med. 61: 1015, 1964). Although most of the findings of the authors are in agreement with ours, there are several points that deserve comment and clarification.
1. The method used by the authors to determine serum CPK activity is based on the "forward" reaction. This method is known to be less sensitive than those based on the "reverse" reaction (1). In our experience with the "forward" reaction, we obtained some zero
GRAIG FA, SMITH JC. SERUM CREATINE PHOSPHOKINASE (CPK). Ann Intern Med. ;62:854–855. doi: 10.7326/0003-4819-62-4-854
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Published: Ann Intern Med. 1965;62(4):854-855.
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